background
A number of studies have confirmed that when the solid material is ultrafinely crushed in the pharmaceutical production process to a size of micrometers or even nanometers, the physical and chemical properties of the substance will change greatly, which will significantly increase the dissolution rate of the drug. And can reduce the toxic side effects of drugs. Regardless of internal or external use, can significantly improve the efficacy. Especially in the field of traditional Chinese medicine, ultra-micro crushing technology can change the traditional Chinese medicine methods. After superfine pulverization and refinement, Chinese herbal medicines can be directly used for oral administration, thereby eliminating the cumbersome process of decoction pieces and decocting, which greatly facilitates patients. The use of medicines; not only so, after research shows that the amount of ultra-micronized Chinese medicine is only equivalent to one-tenth the amount of the original prescription drug, which greatly saves precious Chinese herbal medicine resources, but also effectively protect the cultivation environment of Chinese herbal medicines. In addition, through the ultrafine grinding technology, the insoluble or slightly water-soluble effective products, after cell wall breaking, can significantly increase the bioavailability of drugs. This has created a whole new approach for the development of Chinese medicine into the world.
As a new technology, ultra-micro crushing technology has gradually been taken seriously by China's relevant research and pharmaceutical industries since the 1990s. Many theories of this technology are still in an exploratory stage. With the continuous improvement and development of measurement technology and crushing theory, "ultra-micro crushing technology and ultrafine crusher" will be more widely used in the pharmaceutical industry in China.
Ultramicro crushing technology is a new technology that has emerged in the past decade. It has greatly extended the concept of crushing based on the traditional crushing technology. Among various ultrafine pulverizing machinery and equipments, there are currently air flow pulverizers (mainly including five basic types: horizontal disk type air flow pulverizer, circulating tube type air flow pulverizer, counter-flow counter current air pulverizer, impact plate target type Jet mills and fluidized bed jet mills are widely used in the pharmaceutical industry. In the jet mills, fluidized bed jet mills are the most widely used.
There are three kinds of defects in traditional equipment
The main system of the large fluidized bed air flow ultrafine crusher consists of an air compressor, an air purifier system, a supersonic air flow crusher, a classifier, and a cyclone separator. The medium and small fluidized bed air flow ultrafine crushers usually combine the supersonic air flow crusher, the classifier and the cyclone separator into one machine, which can greatly save the floor space and facilitate installation, transportation and use.
At present, the fluidized-bed airflow ultrafine crusher used in the pharmaceutical industry in production covers multiple nozzles, fluidized beds, horizontal grading, and gas sealing technologies to achieve diversified flow fields and material laminar flow. State and horizontal hierarchical system. However, since the nozzles designed by this comminution mode are arranged in parallel and symmetrically along the inner wall of the crushing chamber, only the shots are formed in a single plane (that is, the horizontal jet is sprayed), so that the materials to be crushed can only be in an approximate plane. Crushing within range, which leads to the following defects:
1. The bottom of the crushing chamber is convenient for unloading. All of them are designed into a conical shape. The material sent into the crushing chamber by the feeding device once enters the cone located below the crushing chamber, the material enters a blind zone and cannot continue. Crushed.
Second, the crushing area is limited to an approximately flat area, and the area is narrow, so that there is relatively less chance for the material to be entrained, impacted, squeezed, and rubbed by the air stream.
Third, the traditional structure makes the material in the process of being crushed, its fluidization state is limited to the top of the nozzle, and the material deposited in the cone below the grinding chamber can not form a fluidized state.
The above defects are the main reason for the high energy consumption and low efficiency of the traditional fluidized bed micro-flow mill.
New equipment to achieve "three-dimensional injection"
In view of these defects in the traditional fluidized bed ultrafine jet mill, the researchers of Beijing Weilin Huxin Machinery Equipment Co., Ltd., after more than ten years of research and development, successfully developed new nozzles by changing the nozzle settings of the traditional mill. A fluidized bed type air flow ultrafine pulverizer--medical grade WLFM-P special model, and applied for a national patent.
The nozzles of the series are located in the same plane around the crushing chamber, forming a certain angle with the plane, and the nozzles are symmetrical downward. At the same time, a vertical upward nozzle is set in the center below the crushing chamber, and all nozzle centerlines are common. Meet at one point and the resultant force is zero. This type of nozzle arrangement breaks through the drawbacks of the traditional fluidized bed jet mill that the comminution area is similar to the plane. Verified by the production practice, compared with the traditional models, the new models can increase the efficiency by 1 to 2 times under the same energy consumption, which greatly reduces the production cost.
A number of studies have confirmed that when the solid material is ultrafinely crushed in the pharmaceutical production process to a size of micrometers or even nanometers, the physical and chemical properties of the substance will change greatly, which will significantly increase the dissolution rate of the drug. And can reduce the toxic side effects of drugs. Regardless of internal or external use, can significantly improve the efficacy. Especially in the field of traditional Chinese medicine, ultra-micro crushing technology can change the traditional Chinese medicine methods. After superfine pulverization and refinement, Chinese herbal medicines can be directly used for oral administration, thereby eliminating the cumbersome process of decoction pieces and decocting, which greatly facilitates patients. The use of medicines; not only so, after research shows that the amount of ultra-micronized Chinese medicine is only equivalent to one-tenth the amount of the original prescription drug, which greatly saves precious Chinese herbal medicine resources, but also effectively protect the cultivation environment of Chinese herbal medicines. In addition, through the ultrafine grinding technology, the insoluble or slightly water-soluble effective products, after cell wall breaking, can significantly increase the bioavailability of drugs. This has created a whole new approach for the development of Chinese medicine into the world.
As a new technology, ultra-micro crushing technology has gradually been taken seriously by China's relevant research and pharmaceutical industries since the 1990s. Many theories of this technology are still in an exploratory stage. With the continuous improvement and development of measurement technology and crushing theory, "ultra-micro crushing technology and ultrafine crusher" will be more widely used in the pharmaceutical industry in China.
Ultramicro crushing technology is a new technology that has emerged in the past decade. It has greatly extended the concept of crushing based on the traditional crushing technology. Among various ultrafine pulverizing machinery and equipments, there are currently air flow pulverizers (mainly including five basic types: horizontal disk type air flow pulverizer, circulating tube type air flow pulverizer, counter-flow counter current air pulverizer, impact plate target type Jet mills and fluidized bed jet mills are widely used in the pharmaceutical industry. In the jet mills, fluidized bed jet mills are the most widely used.
There are three kinds of defects in traditional equipment
The main system of the large fluidized bed air flow ultrafine crusher consists of an air compressor, an air purifier system, a supersonic air flow crusher, a classifier, and a cyclone separator. The medium and small fluidized bed air flow ultrafine crushers usually combine the supersonic air flow crusher, the classifier and the cyclone separator into one machine, which can greatly save the floor space and facilitate installation, transportation and use.
At present, the fluidized-bed airflow ultrafine crusher used in the pharmaceutical industry in production covers multiple nozzles, fluidized beds, horizontal grading, and gas sealing technologies to achieve diversified flow fields and material laminar flow. State and horizontal hierarchical system. However, since the nozzles designed by this comminution mode are arranged in parallel and symmetrically along the inner wall of the crushing chamber, only the shots are formed in a single plane (that is, the horizontal jet is sprayed), so that the materials to be crushed can only be in an approximate plane. Crushing within range, which leads to the following defects:
1. The bottom of the crushing chamber is convenient for unloading. All of them are designed into a conical shape. The material sent into the crushing chamber by the feeding device once enters the cone located below the crushing chamber, the material enters a blind zone and cannot continue. Crushed.
Second, the crushing area is limited to an approximately flat area, and the area is narrow, so that there is relatively less chance for the material to be entrained, impacted, squeezed, and rubbed by the air stream.
Third, the traditional structure makes the material in the process of being crushed, its fluidization state is limited to the top of the nozzle, and the material deposited in the cone below the grinding chamber can not form a fluidized state.
The above defects are the main reason for the high energy consumption and low efficiency of the traditional fluidized bed micro-flow mill.
New equipment to achieve "three-dimensional injection"
In view of these defects in the traditional fluidized bed ultrafine jet mill, the researchers of Beijing Weilin Huxin Machinery Equipment Co., Ltd., after more than ten years of research and development, successfully developed new nozzles by changing the nozzle settings of the traditional mill. A fluidized bed type air flow ultrafine pulverizer--medical grade WLFM-P special model, and applied for a national patent.
The nozzles of the series are located in the same plane around the crushing chamber, forming a certain angle with the plane, and the nozzles are symmetrical downward. At the same time, a vertical upward nozzle is set in the center below the crushing chamber, and all nozzle centerlines are common. Meet at one point and the resultant force is zero. This type of nozzle arrangement breaks through the drawbacks of the traditional fluidized bed jet mill that the comminution area is similar to the plane. Verified by the production practice, compared with the traditional models, the new models can increase the efficiency by 1 to 2 times under the same energy consumption, which greatly reduces the production cost.
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