When China's Mass Spectrometers Start Again
Speaking of mass spectrometry, we must first talk about mass spectrometry in China. According to incomplete statistics, in 2011, the number of various types of mass spectrometers imported from China reached more than 6,000. However, there are few Chinese manufacturers in such a huge market, and the technical gap is the main reason. According to Mr. Li Xuanpei, chief engineer of Beijing East-West Analytical Instrument Co., Ltd., “The development of mass spectrometers in China began in 1959 when the Soviet Union assisted in the preparation of the Beijing Analytical Instrument Factory (North Branch) and its leading product was a mass spectrometer. The plant produced a total of dozens of magnetic mass spectrometers. Since the Cultural Revolution in 1965, production and scientific research relating to mass spectrometry have been at a standstill due to the Cultural Revolution. At this time, the development of mass spectrometry technology in the world is extremely active, especially in color quality. Joint technology has entered a new era.After the reform and opening up, China began to introduce related technologies from abroad, but through the introduction of discovery, the gap between us was too great.Since then, a large number of foreign mass spectrometry products have begun to flood into China. â€
At this point, the first “breakout†of mass spectrometry in China ended in failure, while the re-departure time of mass spectrometry in China came to the 21st century. In 2006, the year of the Chinese instrument industry was remembered. This year, East-West analysis introduced the first domestic commercial quadrupole GC-MS3100, breaking the silence of China in the laboratory mass spectrometer market for nearly 30 years. This blew the clarion call for the resumption of Chinese mass spectrometry. Subsequently, a group of domestic manufacturers, such as General Analysis, Haoyu Hengping, Concentration Technology, Yanxin, Yixing Xinye and Tianrui Instruments, have also joined the mass spectrometry team in China. The product range has also expanded from a single quadrupole to an ion trap. , time-of-flight mass spectrometry, extending from laboratory benchtop mass spectrometry to on-board, in-vehicle, and portable mass spectrometry. (For details, see Table 1)
Among the domestic mass spectrometer products listed in Table I, GC-MS3100 for East-West analysis, Mars-400 for Concentration Technology, and SPAMS 05 for Lucent have significant milestones. The GC-MS3100 marked the start of China's mass spectrometry, and due to her launch, related products of foreign instrument companies had to reduce their prices. According to Mr. Su Yansong, the East-West analysis project manager, the product has sold 30-40 units. Mars-400 is the first portable ion trap GC/MS in China. Her appearance has broken the long-term monopoly of foreign companies in this market, and Mars-400 won the BCEIA Gold Award at BCEIA 2011. SPAMS 05 is a mass spectrometry product developed by Dr. Zhou Zhen after six years of research and development. Its unique application market makes it one of the only two suppliers of such mass spectrometry products in the world, and the product has brought tens of millions of yuan to Ruan Xin. Sales.
Of course, in China's huge mass-spectrum market, the voice of Chinese manufacturers is still very weak. In an interview with the chairman of the Chinese Mass Spectrometry Society of the Chinese mainland, the United States, China Taiwan, and Hong Kong, four of them all stated that there are also mass spectrometers in China. A long way to go is to prepare for a "protracted war." It will take time to "prominently encirclement." However, we are delighted to see that more and more domestic manufacturers have turned their sights on mass spectrometry and plan to join the Mass Spectrometry Force in China; and the state has also paid more attention to mass spectrometry, and launched the “National Major Scientific Instruments and Equipment Development Special Project†launched in 2011. Among them, there are 8 projects involving mass spectrometry, and the amount of funds disclosed has reached about 330 million yuan (see Table 2 for details). Therefore, we have reason to have confidence in the breakthrough of mass spectrometry in China.
In an interview with the “Special Interview†mass spectrometry series, the mass spectrometer ion source technology has been paid attention to many times. As we all know, the ion source is one of the core components of mass spectrometry, and it largely determines the sensitivity of mass spectrometry. In 2002, two soft ionization-electrospray ionization sources (ESI) and matrix-assisted laser desorption and ionization (MALDI) technologies, which were born in the 1980s, shared the Nobel Prize in Chemistry that year. Their revolution lies in making the organism large. Mass spectrometry analysis of molecules has become possible, and mass spectrometry has also been applied to a wider range of fields.
In recent years, some manufacturers have made some improvements and innovations around the classical electrospray ionization technology. For example, in 2002, Advion BioSciences of the United States launched the TriVersa NanoMate®, a fully automatic nanospray ionization source based on nanochip technology. According to Professor Jack Henion, inventor of NanoMate®, “NanoMate® combines fractional collection with electrospray on-chip technology, combining mass spectrometry with liquid-phase technology to provide more information for analyzing complex samples, especially for protein identification, Pharmaceutical analysis, metabolomics, lipidomics, and other studies involving complex matrices and analytes."
Bruck launched the Captive Spray electrospray ion source in 2011. The ion source technology comes from Michrom Bioresources, which Bruker acquired in 2011. According to Dr. Brooke Puhai, “The key point of the Captive Spray technology is the gas flow focusing technology, which can achieve the nanoliter spray sensitivity without nozzle adjustment device. At the same time, Captive Spray technology can directly use air, the spray is stable, and the reproducibility is good. , is an ideal analytical technique for protein identification and quantification."
In this regard, Chinese manufacturers have also made breakthroughs. The company was founded in late 2010 and has launched a sealed adjustable atmosphere electrospray ion source in 2011. Mr. Zhu Yixin, Chairman of Biocosmos, said, “The big drawback of ESI is that it cannot shield the surrounding atmosphere from interference, and it is completely closed. The concept is based on this concept, which is controlled by the ionization atmosphere of the electrospray ion source, resulting in the combination of field-induced hydrogen ions, polarization of polar molecules in high electric fields, and electrostatic adsorption. With a wider range of applications and higher performance than traditional electrospray ion sources."
In addition, direct analysis of ion sources is another major innovation in recent years for mass spectrometer ion sources. According to Prof. Xie Jiantai, director of the Taiwan Mass Spectrometry Society, "It is a trend for mass spectrometry to detect ions in a non-vacuum state. At present, only ion sources can be placed in the atmosphere." Purdue University, 2002. Prof. Graham Cooks introduced the direct analysis of ion source DESI for the first time. Later, many scientists also joined the direct analysis of ion source development, including Chinese scientists such as Professor Zhang Xinrong of Tsinghua University and Professor Chen Huanwen of East China Institute of Technology. Also extended to DART, DBDI, EESI, DCBI, ELDI and ASAP.
Among these technologies, the most successful commercialization at present is the DART ion source. The DART ion source was jointly commercialized by JEOL and IonSense in 2005; in the same year, the product won the Pittcon Writer Gold Award and the R&D 100 Innovation Award. According to Dr. Brian Musselman, President and CEO of IonSense, "At present, the DART ion source has been developed to the fourth generation ID CUBETM, which is more compact, easier to operate and lower operating costs."
In 2012, the Pittcon writer's bronze award, Protea Biosciences' LAESI DP-1000 system, was also a direct analysis source. LAESI (laser ablation electrospray) uses a focused infrared laser beam to produce a small volume of non-ionized material that is electrospray ionized and analyzed by mass spectrometry. According to Gary L., a mass spectrometry expert at the University of North Carolina. According to Glish, “Other commercially available atmospheric ionization sources do not use lasers. This method simplifies the analysis of non-volatile and thermally unstable compounds and improves imaging capabilities.â€
In addition, R. The new QuantIon ion source recently developed by Professor Graham Cooks is a new direct ion source. According to Assistant Professor Ouyang Zheng from Purdue University, “QuantIon is a paper spray ionization source that meets the need for fast and direct analysis of biological fluid samples without the need for sample preparation.â€
The future pattern of the mass spectrometry market is “a fierce battleâ€
Ten years ago, there were only a handful of mass spectrometer suppliers. Today, with the increasing complexity of analytical materials, the demand for mass spectrometry is also increasing, and a huge market attracts more and more manufacturers to join the ranks of mass spectrometry suppliers. It can be predicted that the future pattern of the mass spectrometry market will be "a fierce battle."
At present, in the mass spectrometry market, mainstream suppliers include Thermo Fisher, Agilent, Waters, Bruker, AB SCIEX, Shimadzu, PerkinElmer, etc., and triple quadrupole mass spectrometry and Q-TOF mass spectrometry are various types of mass spectrometry. The application is more extensive and the type of demand is larger. At the same time, the market competition is also the most fierce. In addition, Thermo Fisher's Orbitrap Mass Spectrometer, AB SCIEX's QTRAP Mass Spectrometer, and Shimadzu's IT-TOF Mass Spectrometer are unique products on the market among the three manufacturers.
Prior to 2010, Shimadzu did not have a triple quadrupole liquid product. It was the huge business opportunities in the triple quadrupole liquid market that Shimadzu had introduced to the LCMS-8030. Shi Atsu, US General Manager, Life Sciences Marketing, Scott A. Mr. Kuzdzal believes that "in a very short period of time, the demand for triple quadrupole mass spectrometers will show explosive growth, becoming the largest share of the various mass spectrometry markets, and the market competition for triple quadrupole mass spectrometers will be Global or in China will intensify, and applications will continue to expand, such as the clinical field; many mass spectrometry manufacturers will focus on UHPLC and triple quadrupole mass spectrometry. In 2012, Shimadzu at ASMS (American Mass Spectrometry Annual Meeting) ) Unicom introduced three triple quadrupole mass spectrometer products GCMS-TQ8030, LCMS-8040 and LCMS-8080.
PerkinElmer and Bruck are also seeing opportunities in the mass spectrometry segment to enter the new market for mass spectrometry through acquisitions. In 2009, PerkinElmer acquired ESI inventor John B. Prof. Fenn founded the Analytica of Branford, followed by the introduction of PerkinElmer's first liquid product, the FlexarTM SQ 300 MS, in 2010. In 2011, it introduced the time-of-flight mass spectrometer AxION 2 TOF-MS. Prior to this, PerkinElmer only had an inorganic mass spectrometry product, ICP-MS (inductively coupled plasma mass spectrometry).
Bruker has been focusing on the high-end mass spectrometry market for many years. In 2010, due to Agilent’s acquisition of Varian’s antitrust restrictions, Bruker acquired three product lines: Varian Triple Quadrupole GC/MS, Gas Chromatography and Inductively Coupled Plasma Mass Spectrometry. This also led to the GC-MS and ICP-MS markets. In 2011, we introduced the aurora M90 ICP-MS, the GC-MS SCION SQ, and the SCION TQ, and its new triple quadrupole GC/MS SCION TQ Winner of the 2012 Pittcon Writer Silver Award. Dr. Ian Sanders, Executive Vice President of Bruker Dalton, said, “Q-TOF and TOF/TOF are definitely our main development products. In addition, after we acquired the original Varian three product lines and Michrom Bioresources, we are in the gas triple. The strength of the rod mass spectrum is greatly enhanced, and triple quadrupole liquid quality is also the focus of our research and development."
The latest entrant to be mentioned last is the company of the company. As we all know, the company is a leader in elemental analysis equipment, but at Pittcon 2011, the company's time-of-flight LC/MS CitiusTM LC-HRT won the company’s annual mass production. Pittcon Writer Gold Award. According to Zhuang Jun, Vice President of the Asia Pacific and Africa Region of the company, “Folded Flight Path (FFPTM) technology can achieve ion loss in the LC-HRT mass spectrometer after 64 reflections. 40%, which achieves very high resolution."
For the company's future mass spectrometry development strategy, Mr. Zhuang Xiaochen said, “We believe that there will be greater growth in the future in the field of separation, so we will strengthen our efforts in chromatography, time-of-flight mass spectrometry, quadrupole mass spectrometry and MS/MS. In the next 3-5 years, we will have more new mass spec product launches, but we will not develop products that are currently highly competitive, such as Q-TOF, our products have their own characteristics and market positioning. So currently only TOF products are being developed."
Speaking of mass spectrometry, we must first talk about mass spectrometry in China. According to incomplete statistics, in 2011, the number of various types of mass spectrometers imported from China reached more than 6,000. However, there are few Chinese manufacturers in such a huge market, and the technical gap is the main reason. According to Mr. Li Xuanpei, chief engineer of Beijing East-West Analytical Instrument Co., Ltd., “The development of mass spectrometers in China began in 1959 when the Soviet Union assisted in the preparation of the Beijing Analytical Instrument Factory (North Branch) and its leading product was a mass spectrometer. The plant produced a total of dozens of magnetic mass spectrometers. Since the Cultural Revolution in 1965, production and scientific research relating to mass spectrometry have been at a standstill due to the Cultural Revolution. At this time, the development of mass spectrometry technology in the world is extremely active, especially in color quality. Joint technology has entered a new era.After the reform and opening up, China began to introduce related technologies from abroad, but through the introduction of discovery, the gap between us was too great.Since then, a large number of foreign mass spectrometry products have begun to flood into China. â€
At this point, the first “breakout†of mass spectrometry in China ended in failure, while the re-departure time of mass spectrometry in China came to the 21st century. In 2006, the year of the Chinese instrument industry was remembered. This year, East-West analysis introduced the first domestic commercial quadrupole GC-MS3100, breaking the silence of China in the laboratory mass spectrometer market for nearly 30 years. This blew the clarion call for the resumption of Chinese mass spectrometry. Subsequently, a group of domestic manufacturers, such as General Analysis, Haoyu Hengping, Concentration Technology, Yanxin, Yixing Xinye and Tianrui Instruments, have also joined the mass spectrometry team in China. The product range has also expanded from a single quadrupole to an ion trap. , time-of-flight mass spectrometry, extending from laboratory benchtop mass spectrometry to on-board, in-vehicle, and portable mass spectrometry. (For details, see Table 1)
Among the domestic mass spectrometer products listed in Table I, GC-MS3100 for East-West analysis, Mars-400 for Concentration Technology, and SPAMS 05 for Lucent have significant milestones. The GC-MS3100 marked the start of China's mass spectrometry, and due to her launch, related products of foreign instrument companies had to reduce their prices. According to Mr. Su Yansong, the East-West analysis project manager, the product has sold 30-40 units. Mars-400 is the first portable ion trap GC/MS in China. Her appearance has broken the long-term monopoly of foreign companies in this market, and Mars-400 won the BCEIA Gold Award at BCEIA 2011. SPAMS 05 is a mass spectrometry product developed by Dr. Zhou Zhen after six years of research and development. Its unique application market makes it one of the only two suppliers of such mass spectrometry products in the world, and the product has brought tens of millions of yuan to Ruan Xin. Sales.
Of course, in China's huge mass-spectrum market, the voice of Chinese manufacturers is still very weak. In an interview with the chairman of the Chinese Mass Spectrometry Society of the Chinese mainland, the United States, China Taiwan, and Hong Kong, four of them all stated that there are also mass spectrometers in China. A long way to go is to prepare for a "protracted war." It will take time to "prominently encirclement." However, we are delighted to see that more and more domestic manufacturers have turned their sights on mass spectrometry and plan to join the Mass Spectrometry Force in China; and the state has also paid more attention to mass spectrometry, and launched the “National Major Scientific Instruments and Equipment Development Special Project†launched in 2011. Among them, there are 8 projects involving mass spectrometry, and the amount of funds disclosed has reached about 330 million yuan (see Table 2 for details). Therefore, we have reason to have confidence in the breakthrough of mass spectrometry in China.
In an interview with the “Special Interview†mass spectrometry series, the mass spectrometer ion source technology has been paid attention to many times. As we all know, the ion source is one of the core components of mass spectrometry, and it largely determines the sensitivity of mass spectrometry. In 2002, two soft ionization-electrospray ionization sources (ESI) and matrix-assisted laser desorption and ionization (MALDI) technologies, which were born in the 1980s, shared the Nobel Prize in Chemistry that year. Their revolution lies in making the organism large. Mass spectrometry analysis of molecules has become possible, and mass spectrometry has also been applied to a wider range of fields.
In recent years, some manufacturers have made some improvements and innovations around the classical electrospray ionization technology. For example, in 2002, Advion BioSciences of the United States launched the TriVersa NanoMate®, a fully automatic nanospray ionization source based on nanochip technology. According to Professor Jack Henion, inventor of NanoMate®, “NanoMate® combines fractional collection with electrospray on-chip technology, combining mass spectrometry with liquid-phase technology to provide more information for analyzing complex samples, especially for protein identification, Pharmaceutical analysis, metabolomics, lipidomics, and other studies involving complex matrices and analytes."
Bruck launched the Captive Spray electrospray ion source in 2011. The ion source technology comes from Michrom Bioresources, which Bruker acquired in 2011. According to Dr. Brooke Puhai, “The key point of the Captive Spray technology is the gas flow focusing technology, which can achieve the nanoliter spray sensitivity without nozzle adjustment device. At the same time, Captive Spray technology can directly use air, the spray is stable, and the reproducibility is good. , is an ideal analytical technique for protein identification and quantification."
In this regard, Chinese manufacturers have also made breakthroughs. The company was founded in late 2010 and has launched a sealed adjustable atmosphere electrospray ion source in 2011. Mr. Zhu Yixin, Chairman of Biocosmos, said, “The big drawback of ESI is that it cannot shield the surrounding atmosphere from interference, and it is completely closed. The concept is based on this concept, which is controlled by the ionization atmosphere of the electrospray ion source, resulting in the combination of field-induced hydrogen ions, polarization of polar molecules in high electric fields, and electrostatic adsorption. With a wider range of applications and higher performance than traditional electrospray ion sources."
In addition, direct analysis of ion sources is another major innovation in recent years for mass spectrometer ion sources. According to Prof. Xie Jiantai, director of the Taiwan Mass Spectrometry Society, "It is a trend for mass spectrometry to detect ions in a non-vacuum state. At present, only ion sources can be placed in the atmosphere." Purdue University, 2002. Prof. Graham Cooks introduced the direct analysis of ion source DESI for the first time. Later, many scientists also joined the direct analysis of ion source development, including Chinese scientists such as Professor Zhang Xinrong of Tsinghua University and Professor Chen Huanwen of East China Institute of Technology. Also extended to DART, DBDI, EESI, DCBI, ELDI and ASAP.
Among these technologies, the most successful commercialization at present is the DART ion source. The DART ion source was jointly commercialized by JEOL and IonSense in 2005; in the same year, the product won the Pittcon Writer Gold Award and the R&D 100 Innovation Award. According to Dr. Brian Musselman, President and CEO of IonSense, "At present, the DART ion source has been developed to the fourth generation ID CUBETM, which is more compact, easier to operate and lower operating costs."
In 2012, the Pittcon writer's bronze award, Protea Biosciences' LAESI DP-1000 system, was also a direct analysis source. LAESI (laser ablation electrospray) uses a focused infrared laser beam to produce a small volume of non-ionized material that is electrospray ionized and analyzed by mass spectrometry. According to Gary L., a mass spectrometry expert at the University of North Carolina. According to Glish, “Other commercially available atmospheric ionization sources do not use lasers. This method simplifies the analysis of non-volatile and thermally unstable compounds and improves imaging capabilities.â€
In addition, R. The new QuantIon ion source recently developed by Professor Graham Cooks is a new direct ion source. According to Assistant Professor Ouyang Zheng from Purdue University, “QuantIon is a paper spray ionization source that meets the need for fast and direct analysis of biological fluid samples without the need for sample preparation.â€
The future pattern of the mass spectrometry market is “a fierce battleâ€
Ten years ago, there were only a handful of mass spectrometer suppliers. Today, with the increasing complexity of analytical materials, the demand for mass spectrometry is also increasing, and a huge market attracts more and more manufacturers to join the ranks of mass spectrometry suppliers. It can be predicted that the future pattern of the mass spectrometry market will be "a fierce battle."
At present, in the mass spectrometry market, mainstream suppliers include Thermo Fisher, Agilent, Waters, Bruker, AB SCIEX, Shimadzu, PerkinElmer, etc., and triple quadrupole mass spectrometry and Q-TOF mass spectrometry are various types of mass spectrometry. The application is more extensive and the type of demand is larger. At the same time, the market competition is also the most fierce. In addition, Thermo Fisher's Orbitrap Mass Spectrometer, AB SCIEX's QTRAP Mass Spectrometer, and Shimadzu's IT-TOF Mass Spectrometer are unique products on the market among the three manufacturers.
Prior to 2010, Shimadzu did not have a triple quadrupole liquid product. It was the huge business opportunities in the triple quadrupole liquid market that Shimadzu had introduced to the LCMS-8030. Shi Atsu, US General Manager, Life Sciences Marketing, Scott A. Mr. Kuzdzal believes that "in a very short period of time, the demand for triple quadrupole mass spectrometers will show explosive growth, becoming the largest share of the various mass spectrometry markets, and the market competition for triple quadrupole mass spectrometers will be Global or in China will intensify, and applications will continue to expand, such as the clinical field; many mass spectrometry manufacturers will focus on UHPLC and triple quadrupole mass spectrometry. In 2012, Shimadzu at ASMS (American Mass Spectrometry Annual Meeting) ) Unicom introduced three triple quadrupole mass spectrometer products GCMS-TQ8030, LCMS-8040 and LCMS-8080.
PerkinElmer and Bruck are also seeing opportunities in the mass spectrometry segment to enter the new market for mass spectrometry through acquisitions. In 2009, PerkinElmer acquired ESI inventor John B. Prof. Fenn founded the Analytica of Branford, followed by the introduction of PerkinElmer's first liquid product, the FlexarTM SQ 300 MS, in 2010. In 2011, it introduced the time-of-flight mass spectrometer AxION 2 TOF-MS. Prior to this, PerkinElmer only had an inorganic mass spectrometry product, ICP-MS (inductively coupled plasma mass spectrometry).
Bruker has been focusing on the high-end mass spectrometry market for many years. In 2010, due to Agilent’s acquisition of Varian’s antitrust restrictions, Bruker acquired three product lines: Varian Triple Quadrupole GC/MS, Gas Chromatography and Inductively Coupled Plasma Mass Spectrometry. This also led to the GC-MS and ICP-MS markets. In 2011, we introduced the aurora M90 ICP-MS, the GC-MS SCION SQ, and the SCION TQ, and its new triple quadrupole GC/MS SCION TQ Winner of the 2012 Pittcon Writer Silver Award. Dr. Ian Sanders, Executive Vice President of Bruker Dalton, said, “Q-TOF and TOF/TOF are definitely our main development products. In addition, after we acquired the original Varian three product lines and Michrom Bioresources, we are in the gas triple. The strength of the rod mass spectrum is greatly enhanced, and triple quadrupole liquid quality is also the focus of our research and development."
The latest entrant to be mentioned last is the company of the company. As we all know, the company is a leader in elemental analysis equipment, but at Pittcon 2011, the company's time-of-flight LC/MS CitiusTM LC-HRT won the company’s annual mass production. Pittcon Writer Gold Award. According to Zhuang Jun, Vice President of the Asia Pacific and Africa Region of the company, “Folded Flight Path (FFPTM) technology can achieve ion loss in the LC-HRT mass spectrometer after 64 reflections. 40%, which achieves very high resolution."
For the company's future mass spectrometry development strategy, Mr. Zhuang Xiaochen said, “We believe that there will be greater growth in the future in the field of separation, so we will strengthen our efforts in chromatography, time-of-flight mass spectrometry, quadrupole mass spectrometry and MS/MS. In the next 3-5 years, we will have more new mass spec product launches, but we will not develop products that are currently highly competitive, such as Q-TOF, our products have their own characteristics and market positioning. So currently only TOF products are being developed."
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